: Bioinformatics



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Johns Hopkins Medicine | Sidney Kimmel Comprehensive Cancer Center


Research in the Oncology Bioinformatics group within the Quantitative Sciences Program focuses on the elucidation of fundamental biological behaviors in cancer and the development of biomarkers to inform prognosis and guide therapy. Researchers work specifically in the areas of epigenomics and genomics, with methodological development often coupled to collaborative research with other cancer center programs, which accelerates translation to clinical utility.

Ongoing methodological research is focused in four main areas: 1) sequence interpretation, 2) genomic variation related to cancer etiology, 3) epigenomic analysis, and 3) genomics data integration. New techniques are being created for the mathematical analysis and biological interpretation of sequencing data, especially next generation sequencing coupled to other high-dimensional data sets. Statistical methods and dimensionality reduction approaches are being developed for SNP and copy number variation determination and identification of driver epigenetic changes in cancer, including signature development, cell line and xenograft model validation, and clinical development. Data integration approaches, especially in the area of multiple high-throughput platforms, are being developed and applied in areas of pathway analysis and network approaches to understanding drug resistance.

The Bioinformatics Working Group includes seven faculty members from the Quantitative Sciences and Cancer Biology Programs in the Sidney Kimmel Comprehensive Cancer Center, as well as associated postdoctoral fellows and graduate students.

Bioinformatics Working Group

Oncology Bioinformatics
Wednesdays at 1:00 PM in Rm 1131 in the 550 Building