: Research: Xiaobu Ye M.D., M.S.
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Johns Hopkins Medicine | Sidney Kimmel Comprehensive Cancer Center

Xiaobu Ye M.D., M.S.

Research Summary: Xiaobu Ye is an Associate Professor of Neurosurgery and Oncology/Biostatistics at the Johns Hopkins School of Medicine (JHMI). She earned her degrees in medicine and an MS in Biostatistics in 1983 and 1994, respectively. She was a faculty member at the Medical University of South Carolina prior to joining the Division of Oncology Biostatistics at JHMI in 2002. The main interest of her work has been the implementation of statistical methodologies in practical clinical research with an emphasis in clinical trials. Such implementation relies heavily on scientific rationales in medicine, biology and principles of statistics that include using the continual reassessment method (CRM), response surface method, an entropy-based approach, the Bayesian method, and other general statistical methods in anti-cancer therapeutic development.

She also served as a Senior Statistician for the Center for Complementary and Alternative Medicine and SPORE grants at Johns Hopkins. She is the faculty biostatistician for a research training grant in Neuro-Oncology mentoring junior investigators in developing basic clinical research skills.

Since 2003, she has been a statistician for the NCI-funded brain tumor clinical trial consortium (ABTC), a collaboration of multiple academic institutions, pharmaceutical companies, and the NCI Cancer Therapy Evaluation Program (CTEP). She is a member of the NCI Brain Malignancies Steering Committee (BMSC) for biostatistics.
Keywords: Clinical Trials; Brain Tumor; CRM; Surrogate Endpoints